Services we provide
End-to-end or à la carte service, including fresh tissue handling to final report
Custom study design consultation
Sample pick up service from the Texas Medical Center area for rapid sample processing
Cloud-based bioinformatics Pipeline for basic and custom computational analysis
Specialize in clinical trial samples, including biospy core analysis
Tissue Dissociation into single cells
Single cell capture and library generation
UMAP visualization of clusters from scRNA Sequencing analysis
Single Cell Sequencing Service
We offer end-to-end single-cell RNA sequencing service, from tissue dissociation to bioinformatics analysis. Decipher the complexity of each cancer ecosystem through droplet-based single-cell RNA sequencing service, including immune profiling. Elucidating cellular heterogeneity in terms of cell type composition and activation states pre- and post-treatment, for example, can provide profound cellular and molecular level understanding.
Single Cell Gene Expression 3' and 5'
Single Cell Immune Profiling (TCR/BCR sequencing)
Single cell ATAC-seq
The Latest in scRNA Sequencing
Early insights into clinical trials through single-cell RNA sequencing from biopsy cores
Single cell RNA-sequencing (scRNA-seq) yields valuable insights into the molecular
heterogeneity of multiple cell types in normal and cancer tissues
Single Cell RNA-sequencing Analysis from Clinical Trials Needle Biopsy Cores
Single-cell sequencing from 18g needle biopsy cores from clinical trial from multiple tissue types, including liver, lymph node, pelvic bone, abdominal cavity, and lung tissues
Immunity, Jun 2021
Haley L Dugan et al.
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets
Single-cell sequencing was used to describe SARS-CoV-2 B cells, and revealed "antibody adaptation to non-neutralizing intracellular antigens during infection".
Cell Stem Cell, Jun 2021
Ling Huang et al.
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
Organoids mimicking the exocrine pancreas were developed to model "lineage tropism and plasticity for oncogene action in the pancreas". Single-cell RNA sequencing was used to asses molecular differences between organoid lineages.
Nature, Jun 2021
David Liu et al.
Evolution of delayed resistance to immunotherapy in a melanoma responder
Single-Cell RNA sequencing data along with immunofluorescence was used to understand immune resistance in melanoma patients, revealing "differences in immune composition among different lineages".
Nature, Jun 2021
Daniela J Di Bella et al.
Molecular logic of cellular diversification in the mouse cerebral cortex
An atlas of a developing mouse-neocortex was created using single-cell RNA sequencing data to help show "lineage-specific developmental abnormalities" commonly linked to mutations.